Manchester United Team News:
The Red Devils will hope that Kobbie Mainoo is fit enough to start, after the teenage midfielder missed international duty with a tight hamstring.
Bruno Fernandes remains out through suspension after his red card against Tottenham Hotspur, while Leny Yoro, Luke Shaw, Mason Mount, Harry Maguire, Noussair Mazraoui and Alejandro Garnacho all seem likely to miss out.
Predicted lineup: Onana; Lindelöf, De Ligt, Evans, Dalot; Casemiro, Mainoo; Antony, Eriksen, Rashford; Højlund.
Brentford Team News:
Like the home side, Brentford are suffering from a lengthy injury list, with Rico Henry, Igor Thiago, Yoane Wissa, Aaron Hickey, Mathias Jensen, Josh Dasilva and Gustavo Nunes all on the treatment table.
The Bees are likely to stick with the same side that started the win over Wolverhampton Wanderers last weekend.
Predicted lineup: Flekken; Van den Berg, Pinnock, Collins, Ajer; Janelt, Nørgaard, Janelt; Mbeumo, Damsgaard, Lewis-Potter; Schade.