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San Francisco 49ers vs Green Bay Packers Prediction and Betting Odds

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1st Seed vs 7th Seed. But Packers are Lovin’ it.

Need-to-know info

  • Who: Green Bay Packers @ San Francisco 49ers
  • When: Saturday, Jan 20 at 8:15PM ET
  • Where: Levi’s Stadium, Santa Clara, CA
  • How to watch: FOX

San Francisco 49ers vs Green Bay Packers. In the Playoffs. Again. This NFC Divisional Round matchup sets a new record – it’s the tenth time the two franchises have met in the postseason, a feat unmatched by any other pairing.

In the 90s, it was all about Brett Favre and the Cheeseheads. But it’s San Fran on top now with four straight postseason wins – and they’re unsurprisingly favored to extend that streak after securing the top seed with a 12-5 record.

The 49ers are favorites to lift their fifth Lombardi Trophy, but their season hasn’t been plain sailing. A hot start was followed by a three-game slump, before embarking on a winning run that saw them sail to a second straight NFC West title.

It’s that hat-trick of losses which will give Green Bay confidence. The Browns, Bengals and Vikings all beat the 49ers back when they had first-choice Quarterbacks available. Baltimore also beat them in what could be a Super Bowl rehearsal. The pressure is on to deliver.

But deliver, they can. The 49ers offense is loaded with stars. He might not be getting the MVP award, but Christian McCaffrey has been the best player in the NFL this year. Deebo Samuel, Brandon Aiyuk and George Kittle are just a few more of the offensive weapons that have made San Fran too hot to handle this year.

And Green Bay? No Favre, no Rodgers, no problem. The Packers might just have found their next long-term quarterback. Jordan Love was electric down the stretch but took it to the next level on Wildcard Weekend, dominating Dallas in their house.

The connection with Romeo Doubs was jaw-dropping – the rookie pass-catcher hauled in six receptions for 151 yards, plus a touchdown for good measure. It wasn’t all about the offense. Jaire Alexander almost got a pick-six, Darnell Savage did. The Packers raced into a 27-0 lead and at 48-16, pulled their starters.

It was emphatic, it was a statement, and it’s got us very excited for the latest installment of this famous NFL rivalry.

TEAM NEWS: McCaffrey ready to run the show

A calf injury to Christian McCaffrey in Week 17 set alarm bells ringing in San Francisco, but the do-it-all running back has had a couple of weeks of rest and is good to go for the Divisional Round. It was never really in doubt, but a return to full practice can put everyone at ease. Well, except Green Bay. The 49ers are looking healthy for this one.

Team News: Packers rest up for the big one

The Packers are yet to practice at the time of writing due to the short turnaround, but initially had 15 players on the injury report. The biggest concern is Jaire Alexander, whose crucial interception helped the Packers pull away in Dallas. However, Head Coach Matt LaFleur is confident that the star Cornerback will be ready to go.


Linebacker Kingsley Enagbare, who had a team-high two QB hits on Wildcard Weekend, will miss out after a season-ending knee injury against the Cowboys.

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Form Guide

Season Record

San Francisco 49ers: 12-5 (1st in the NFC West)

Green Bay Packers: 9-8 (2nd in the NFC North)


Final Five

49ers: WWLWL

Packers: LLWWW


Previous Meeting

Packers 10-13 49ers (NFC Divisional Round, 2021)

The last meeting between the pair was at this exact stage and it was the usual story, with San Fran winning their fourth straight playoff game against the Packers. This was Aaron Rodgers’ final start against the 49ers – a lot has changed since then.

FlashPicks prediction

First vs Seventh seed should be straightforward. But if the Packers come out like they did against the Cowboys, San Fran might be in trouble. Sometimes a rest doesn’t do you good. This young Green Bay team have plenty of ability and even more potential – but San Francisco 49ers have the talent and experience to get the job done. Should be fun though.

Moneyline Pick: 49ers (-440)

Odds and spreads correct as of 01/17/2024

San Francisco 49ers logo

SF

Seattle Seahawks logo

SEA

NFL | Fri 10/11, 12:15 AM
Jacksonville Jaguars logo

JAX

Chicago Bears logo

CHI

NFL | Sun 10/13, 1:30 PM
Arizona Cardinals logo

ARI

Green Bay Packers logo

GB

NFL | Sun 10/13, 5:00 PM
Cleveland Browns logo

CLE

Philadelphia Eagles logo

PHI

NFL | Sun 10/13, 5:00 PM
Houston Texans logo

HOU

New England Patriots logo

NE

NFL | Sun 10/13, 5:00 PM
Indianapolis Colts logo

IND

Tennessee Titans logo

TEN

NFL | Sun 10/13, 5:00 PM
Tampa Bay Buccaneers logo

TB

New Orleans Saints logo

NO

NFL | Sun 10/13, 5:00 PM
Washington Commanders logo

WAS

Baltimore Ravens logo

BAL

NFL | Sun 10/13, 5:00 PM
Los Angeles Chargers logo

LAC

Denver Broncos logo

DEN

NFL | Sun 10/13, 8:05 PM
Pittsburgh Steelers logo

PIT

Las Vegas Raiders logo

LV

NFL | Sun 10/13, 8:05 PM

Spread Pick: Packers +9.5 (-105)

Odds and spreads correct as of 01/17/2024

San Francisco 49ers logo

SF

Seattle Seahawks logo

SEA

NFL | Fri 10/11, 12:15 AM
Jacksonville Jaguars logo

JAX

Chicago Bears logo

CHI

NFL | Sun 10/13, 1:30 PM
Arizona Cardinals logo

ARI

Green Bay Packers logo

GB

NFL | Sun 10/13, 5:00 PM
Cleveland Browns logo

CLE

Philadelphia Eagles logo

PHI

NFL | Sun 10/13, 5:00 PM
Houston Texans logo

HOU

New England Patriots logo

NE

NFL | Sun 10/13, 5:00 PM
Indianapolis Colts logo

IND

Tennessee Titans logo

TEN

NFL | Sun 10/13, 5:00 PM
Tampa Bay Buccaneers logo

TB

New Orleans Saints logo

NO

NFL | Sun 10/13, 5:00 PM
Washington Commanders logo

WAS

Baltimore Ravens logo

BAL

NFL | Sun 10/13, 5:00 PM
Los Angeles Chargers logo

LAC

Denver Broncos logo

DEN

NFL | Sun 10/13, 8:05 PM
Pittsburgh Steelers logo

PIT

Las Vegas Raiders logo

LV

NFL | Sun 10/13, 8:05 PM

Totals Pick: Over 50.5 (-110)

Odds and spreads correct as of 01/17/2024

San Francisco 49ers logo

SF

Seattle Seahawks logo

SEA

NFL | Fri 10/11, 12:15 AM
Jacksonville Jaguars logo

JAX

Chicago Bears logo

CHI

NFL | Sun 10/13, 1:30 PM
Arizona Cardinals logo

ARI

Green Bay Packers logo

GB

NFL | Sun 10/13, 5:00 PM
Cleveland Browns logo

CLE

Philadelphia Eagles logo

PHI

NFL | Sun 10/13, 5:00 PM
Houston Texans logo

HOU

New England Patriots logo

NE

NFL | Sun 10/13, 5:00 PM
Indianapolis Colts logo

IND

Tennessee Titans logo

TEN

NFL | Sun 10/13, 5:00 PM
Tampa Bay Buccaneers logo

TB

New Orleans Saints logo

NO

NFL | Sun 10/13, 5:00 PM
Washington Commanders logo

WAS

Baltimore Ravens logo

BAL

NFL | Sun 10/13, 5:00 PM
Los Angeles Chargers logo

LAC

Denver Broncos logo

DEN

NFL | Sun 10/13, 8:05 PM
Pittsburgh Steelers logo

PIT

Las Vegas Raiders logo

LV

NFL | Sun 10/13, 8:05 PM

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